Human respiratory coronavirus OC43: Genetic stability and neuroinvasion
Identifieur interne : 005B31 ( Main/Exploration ); précédent : 005B30; suivant : 005B32Human respiratory coronavirus OC43: Genetic stability and neuroinvasion
Auteurs : Julien R. St-Jean [Canada] ; Hélène Jacomy [Canada] ; Marc Desforges [Canada] ; Astrid Vabret [France] ; Francois Freymuth [France] ; Pierre J. Talbot [Canada]Source :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Analyse de séquence d'ADN, Animaux, Biologie informatique, Coronavirus humain OC43 (génétique), Coronavirus humain OC43 (pathogénicité), Coronavirus humain OC43 (physiologie), Données de séquences moléculaires, Encéphale (virologie), Génome viral, Humains, Infections à coronavirus (physiopathologie), Infections à coronavirus (virologie), Lignée cellulaire tumorale, Maladies virales du système nerveux central (physiopathologie), Maladies virales du système nerveux central (virologie), Mutation, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Virulence.
- MESH :
- génétique : Coronavirus humain OC43.
- pathogénicité : Coronavirus humain OC43.
- physiologie : Coronavirus humain OC43.
- physiopathologie : Infections à coronavirus, Maladies virales du système nerveux central.
- virologie : Encéphale, Infections à coronavirus, Maladies virales du système nerveux central.
- Pascal (Inist)
- Analyse de séquence d'ADN, Animaux, Biologie informatique, Données de séquences moléculaires, Génome viral, Homme, Coronavirus OC43 humain, Humains, Lignée cellulaire tumorale, Mutation, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Virulence, Voie respiratoire, Génétique, Microbiologie, Virologie.
- Wicri :
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Brain (virology), Cell Line, Tumor, Central Nervous System Viral Diseases (physiopathology), Central Nervous System Viral Diseases (virology), Computational Biology, Coronavirus Infections (physiopathology), Coronavirus Infections (virology), Coronavirus OC43, Human (genetics), Coronavirus OC43, Human (pathogenicity), Coronavirus OC43, Human (physiology), Genetics, Genome, Viral, Human, Human coronavirus OC43, Humans, Mice, Mice, Inbred BALB C, Microbiology, Molecular Sequence Data, Mutation, Respiratory tract, Sequence Analysis, DNA, Virology, Virulence.
- MESH :
- genetics : Coronavirus OC43, Human.
- pathogenicity : Coronavirus OC43, Human.
- physiology : Coronavirus OC43, Human.
- physiopathology : Central Nervous System Viral Diseases, Coronavirus Infections.
- virology : Brain, Central Nervous System Viral Diseases, Coronavirus Infections.
- Amino Acid Sequence, Animals, Cell Line, Tumor, Computational Biology, Genome, Viral, Humans, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutation, Sequence Analysis, DNA, Virulence.
Abstract
The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained. Both genomes are 30,713 nucleotides long, excluding the poly(A) tail, and only differ by 6 nucleotides. These six mutations are scattered throughout the genome and give rise to only two amino acid substitutions: one in the spike protein gene (I958F) and the other in the nucleocapsid protein gene (V81A). Furthermore, the two variants were shown to reach the central nervous system (CNS) after intranasal inoculation in BALB/c mice, demonstrating neuroinvasive properties. Even though the ATCC strain could penetrate the CNS more effectively than the Paris 2001 isolate, these results suggest that intrinsic neuroinvasive properties already existed for the HCoV-OC43 ATCC human respiratory isolate from the 1960s before it was propagated in newborn mouse brains. It also demonstrates that the molecular structure of HCoV-OC43 is very stable in the environment (the two variants were isolated ca. 40 years apart) despite virus shedding and chances of persistence in the host. The genomes of the two HCoV-OC43 variants display 71, 53.1, and 51.2% identity with those of mouse hepatitis virus A59, severe acute respiratory syndrome human coronavirus Tor2 strain (SARS-HCoV Tor2), and human coronavirus 229E (HCoV-229E), respectively. HCoV-OC43 also possesses well-conserved motifs with regard to the genome sequence of the SARS-HCoV Tor2, especially in open reading frame 1b. These results suggest that HCoV-OC43 and SARS-HCoV may share several important functional properties and that HCoV-OC43 may be used as a model to study the biology of SARS-HCoV without the need for level three biological facilities.
Affiliations:
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<term>Cell Line, Tumor</term>
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<term>Coronavirus humain OC43 (pathogénicité)</term>
<term>Coronavirus humain OC43 (physiologie)</term>
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<front><div type="abstract" xml:lang="en">The complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC), and a HCoV-OC43 clinical isolate, designated Paris, were obtained. Both genomes are 30,713 nucleotides long, excluding the poly(A) tail, and only differ by 6 nucleotides. These six mutations are scattered throughout the genome and give rise to only two amino acid substitutions: one in the spike protein gene (I958F) and the other in the nucleocapsid protein gene (V81A). Furthermore, the two variants were shown to reach the central nervous system (CNS) after intranasal inoculation in BALB/c mice, demonstrating neuroinvasive properties. Even though the ATCC strain could penetrate the CNS more effectively than the Paris 2001 isolate, these results suggest that intrinsic neuroinvasive properties already existed for the HCoV-OC43 ATCC human respiratory isolate from the 1960s before it was propagated in newborn mouse brains. It also demonstrates that the molecular structure of HCoV-OC43 is very stable in the environment (the two variants were isolated ca. 40 years apart) despite virus shedding and chances of persistence in the host. The genomes of the two HCoV-OC43 variants display 71, 53.1, and 51.2% identity with those of mouse hepatitis virus A59, severe acute respiratory syndrome human coronavirus Tor2 strain (SARS-HCoV Tor2), and human coronavirus 229E (HCoV-229E), respectively. HCoV-OC43 also possesses well-conserved motifs with regard to the genome sequence of the SARS-HCoV Tor2, especially in open reading frame 1b. These results suggest that HCoV-OC43 and SARS-HCoV may share several important functional properties and that HCoV-OC43 may be used as a model to study the biology of SARS-HCoV without the need for level three biological facilities.</div>
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